Publications by OncoFusion Scientists

Our research is published in leading scientific journals. Review our published results on ERG/ETS transcription factors, EZH2/PRC2 or MMSET studies.

 


 

ERG/ETS transcription factors

Common gene rearrangements in prostate cancer.

Rubin MA, Maher CA, Chinnaiyan AM. J Clin Oncol. 2011 Sep 20;29(27):3659-68. doi: 10.1200/JCO.2011.35.1916. Epub 2011 Aug 22. Review. PMID: 21859993

 

An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.

Yu J, Yu J, Mani RS, Cao Q, Brenner CJ, Cao X, Wang X, Wu L, Li J, Hu M, Gong Y, Cheng H, Laxman B, Vellaichamy A, Shankar S, Li Y, Dhanasekaran SM, Morey R, Barrette T, Lonigro RJ, Tomlins SA, Varambally S, Qin ZS, Chinnaiyan AM. Cancer Cell. 2010 May 18;17(5):443-54. doi: 10.1016/j.ccr.2010.03.018. PMID: 20478527

 

Induced chromosomal proximity and gene fusions in prostate cancer.

Mani RS, Tomlins SA, Callahan K, Ghosh A, Nyati MK, Varambally S, Palanisamy N, Chinnaiyan AM. Science. 2009 Nov 27;326(5957):1230. doi: 10.1126/ science.1178124. Epub 2009 Oct 29. PMID: 19933109

 

Recurrent gene fusions in prostate cancer.

Kumar-Sinha C, Tomlins SA, Chinnaiyan AM. Nat Rev Cancer. 2008 Jul;8(7):497-511. doi: 10.1038/nrc2402. Epub 2008 Jun 19. Review. PMID: 18563191

 

Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer.

Tomlins SA, Laxman B, Dhanasekaran SM, Helgeson BE, Cao X, Morris DS, Menon A, Jing X, Cao Q, Han B, Yu J, Wang L, Montie JE, Rubin MA, Pienta KJ, Roulston D, Shah RB, Varambally S, Mehra R, Chinnaiyan AM. Nature. 2007 Aug 2;448(7153): 595-9. PMID: 17671502

 

Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.

Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, Sun XW, Varambally S, Cao X, Tchinda J, Kuefer R, Lee C, Montie JE, Shah RB, Pienta KJ, Rubin MA, Chinnaiyan AM. Science. 2005 Oct 28;310(5748):644-8. PMID: 16254181

 


 

EZH2/PRC2

Coordinated regulation of polycomb group complexes through microRNAs in cancer.

Cao Q, Mani RS, Ateeq B, Dhanasekaran SM, Asangani IA, Prensner JR, Kim JH, Brenner JC, Jing X, Cao X, Wang R, Li Y, Dahiya A, Wang L, Pandhi M, Lonigro RJ, Wu YM, Tomlins SA, Palanisamy N, Qin Z, Yu J, Maher CA, Varambally S, Chinnaiyan AM. Cancer Cell. 2011 Aug 16;20(2):187-99. doi: 10.1016/j.ccr.2011.06.016. PMID: 21840484

 

Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer.

Varambally S, Cao Q, Mani RS, Shankar S, Wang X, Ateeq B, Laxman B, Cao X, Jing X, Ramnarayanan K, Brenner JC, Yu J, Kim JH, Han B, Tan P, Kumar-Sinha C, Lonigro RJ, Palanisamy N, Maher CA, Chinnaiyan AM. Science. 2008 Dec 12;322(5908):1695-9. doi: 10.1126/science.1165395. Epub 2008 Nov 13. PMID: 19008416

 

Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer.

Yu J, Cao Q, Mehra R, Laxman B, Yu J, Tomlins SA, Creighton CJ, Dhanasekaran SM, Shen R, Chen G, Morris DS, Marquez VE, Shah RB, Ghosh D, Varambally S, Chinnaiyan AM. Cancer Cell. 2007 Nov;12(5):419-31. PMID: 17996646

 

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells.

Kleer CG, Cao Q, Varambally S, Shen R, Ota I, Tomlins SA, Ghosh D, Sewalt RG, Otte AP, Hayes DF, Sabel MS, Livant D, Weiss SJ, Rubin MA, Chinnaiyan AM. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11606-11. Epub 2003 Sep 19. PMID: 14500907

 

The polycomb group protein EZH2 is involved in progression of prostate cancer.

Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha C, Sanda MG, Ghosh D, Pienta KJ, Sewalt RG, Otte AP, Rubin MA, Chinnaiyan AM. Nature. 2002 Oct 10;419(6907):624-9. PMID: 12374981

 


 

MMSET

Characterization of the EZH2-MMSET Histone Methyltransferase Regulatory Axis in Cancer.

Asangani IA, Ateeq B, Cao Q, Dodson L, Pandhi M, Kunju LP, Mehra R, Lonigro RJ, Siddiqui J, Palanisamy N, Wu YM, Cao X, Kim JH, Zhao M, Qin ZS, Iyer MK, Maher CA, Kumar-Sinha C, Varambally S, Chinnaiyan AM. Mol Cell. 2012 Nov 13. doi:pii: S1097-2765(12)00861-1. 10.1016/ j.molcel.2012.10.008. [Epub ahead of print] PMID: 23159737